How to Slow Aging (and even reverse it)

Scientists like Prof Sinclair have evidence of speeding up, slowing, and even reversing aging.
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What causes aging? According to Professor David Sinclair, it is a loss of information in our epigenome, the system of proteins like histones and chemical markers like methylation that turn on and off genes. Epigenetics allow different cell types to perform their specific functions - they are what differentiate a brain cell from a skin cell. Our DNA is constantly getting broken, by cosmic rays, UV radiation, free radicals, x-rays and regular cell division etc. When our cells repair that damage, the epigenome is not perfectly reset. And hence over time, noise accumulates in our epigenome. Our cells no longer perform their functions well.
To counter this decline, we can activate the body's own defenses against aging by stressing the body. Eat less, eat less protein, engage in intense exercise, experience uncomfortable cold. When the body senses existential threats it triggers longevity genes, which attempt to maintain the body to ensure its survival until good times return. This may be the evolutionary legacy of early bacteria, which established these two modes of living (repair and protect vs grow and reproduce). Scientists are uncovering ways to mimic stresses on the body without the discomfort of fasting. Molecules like NMN also trigger sirtuins to monitor and repair the epigenome. This may slow aging.
Reversing aging requires an epigenetic reset, which may be possible using Yamanaka factors. These four factors can revert an adult cell into a pluripotent stem cell. Prof. Sinclair used three of the four factors to reverse aging in the retinal cells of old mice. He found they could see again after the treatment.
Special thanks to:
Professor David Sinclair, check out his book "Lifespan: Why We Age & Why We Don't Have To"
Assistant Professor David Gold
Noemie Sierra (for polyp images)
Genepool Productions for telomere animations from Immortal:
Epigenetics animations (DNA, histones, methylation etc) courtesy of:
Animation: Etsuko Uno
Art and Technical Direction: Drew Berry
Sound Design: Francois Tetaz & Emma Bortignon
Scientific Consultation: Marnie Blewitt
Courtesy of Walter and Eliza Hall Institute of Medical Research
Filming, editing and animation by Jonny Hyman and Derek Muller
Music from "Clearer Views" "Innovations" "A Sound Foundation" "Seaweed"
Additional music by Kevin MacLeod from "Marty Gots a Plan"


  • Vincent Hall
    Vincent Hall2 orë më parë

    Old human: What am I doing here? Old human's cells: What am I doing here?

  • Veronica
    Veronica3 orë më parë

    The Elites are already able to transfer their consciousness to AI. What they need are bodies. Their clones don't last long. Look up Donald Marshall.

  • alter ego
    alter ego6 orë më parë

    Hi couldnt help but notice the volume differences between your voice and Dr.Sinclairs. And with the current tech on affected phones like mine the disparity becomes so huge that at max volume on speaker your voice booms while can hardly hear him. Still its a super video tq n keep them coming.

  • WBNHS Eugine myles Lacbayen
    WBNHS Eugine myles Lacbayen9 orë më parë

    i thought his beard was getting whiter as the video goes on

  • Obi Juan
    Obi Juan10 orë më parë

    I think that ‘slowing aging’ is the incorrect terminology, we need to extend youth. Extending youth, naturally implies that our longer life is a healthier life.

  • GojiPuddin
    GojiPuddin12 orë më parë

    be uncomfortable, got it lol

  • Rubaeth Hossain
    Rubaeth Hossain14 orë më parë

    hang on. some of the methods sound like saitamas training. 👀

  • Cheyno Mdingi
    Cheyno Mdingi15 orë më parë

    Dude talks about fasting and disease without mentioning insulin once

  • Aziz Al-Azfar
    Aziz Al-Azfar17 orë më parë

    8:43 That's a very uncomfortable laugh.

  • adrian aron
    adrian aron17 orë më parë

    oh the war that will come for immortality

  • Benni B
    Benni B21 orë më parë

    Wow, even if you apply this to the real world and what we consider to be "healthy living" it makes total sense

  • Vladimir Georgiev
    Vladimir GeorgievDitë më parë

    Why copper ions became denser? I think they became smaller. And what if we do the explanation from the point of the copper ion. The cat and the electrons are moving along. There are more electrons and cats? No

  • Hinge 45
    Hinge 45Ditë më parë

    what the point of slowing down aging if you get 2 times slower?

  • {Larry Cosmoc, The Brownie Man}
    {Larry Cosmoc, The Brownie Man}Ditë më parë

    Now we have to add two ages! Biological and physical

  • Squidyy
    SquidyyDitë më parë

    4:29 yes, yes we know

  • kiana Porter
    kiana PorterDitë më parë

    If the eye thing works with rats maybe we can do it with humans that could see but became blind so they can see again

  • Penelope hunter
    Penelope hunterDitë më parë

    So what if your life is a cycle of hospital tests? I do the sun screen, even if moderately warm( altho sun can also be present in winter but you’re rather covered up then, my make up and face lotion is 25 protection, I also have a varied diet of fruit veg, a little chicken occasional mince, yogurt and smoked salmon once a month, due to health issues I can’t exersixe as much as I’d want but I still want to do as much as I can not to damage my genes

  • Elliotttheneko is Elliotttheneko
    Elliotttheneko is ElliottthenekoDitë më parë

    Son... *I am winning.*

  • xXBossManStatusXx
    xXBossManStatusXxDitë më parë

    Now we know why black don’t crack

  • Daniel Addison
    Daniel AddisonDitë më parë

    Makes this video while clearly aging before our faces 😒

  • G's Cheese
    G's CheeseDitë më parë

    Getting halo reach vibes from the song closer to end of the video.

  • scottyGG
    scottyGG2 ditë më parë

    this man is steps away from being an evil genius

  • Martand Dev
    Martand Dev2 ditë më parë

    If having a hair growing on a body part means turning old. Then I have been old for as long as I can remember.

  • Aarya Kapoor
    Aarya Kapoor2 ditë më parë

    why evil he is really trying to do something good also I think even if he found that that won't be public

  • Hoàng Du Trần
    Hoàng Du Trần2 ditë më parë

    15:54 so that's what happened to Deadpool

  • erkbun
    erkbun2 ditë më parë

    >calorie restriction >protein restriction >high intensity training >be uncomfortably cold >be uncomfortably hot So this is why One Punch Man became so powerful. He balded because babies are bald. He reversed aging to an extreme, and kept his adult form.

  • AnSturbin
    AnSturbin2 ditë më parë

    Shoutout to Bret Weinstein for hypothesizing telomere’s relationship to cancer 30 years ago

  • fungalwater
    fungalwater2 ditë më parë

    Imma become baby

  • CZAR
    CZAR2 ditë më parë

    Eatin too much protein is bad? What if i lift weights?

  • Harsh Mehta
    Harsh Mehta2 ditë më parë

    @4:30 when he said zombies : it can be definitely used as biological weapon and trigger senensense cells and could some how potentially turn us into zombies

  • Anastasia
    Anastasia2 ditë më parë

    4:50 On cloning: 1. Aren't donor cells taken from relatively young animals? 2. Only one cell (that may by chance have fewer mutations) at a time will become the embryo and the most viable are selected. 3. Still, are cloned animals really healthy? Aging appears to be a complex process. Accumulating mutations should too play some role. Anyway, they play a huge role in cancer. 7:50 Later, you mention DNA damage... You don't see a contradiction in you narrative?...

  • Anastasia
    Anastasia2 ditë më parë

    2:55 So awkward to hear that from a scientist... Although, I understand that you are not in biology. Stopping aging will not "help us to live forever". This is such a moronic affirmation. People will still die from all sorts of accidents and diseases not related to the old age.

  • Quinn Smith

    Quinn Smith

    Ditë më parë

    Rejuvenation biotechnology won't be "immortality", but it will enable people to live indefinitely as a side effect of perfect health. Technology is all about overcoming nature; all medical conditions will become curable, all accidents will be prevented, people will become more physically durable, ect., so all of the problems that cause death will be cured.

  • Blo Nguyen
    Blo Nguyen3 ditë më parë

    From the thumbnail i thought we could cure blackness LOL

  • Mo Ah
    Mo Ah3 ditë më parë

    Fasting one month a year. Ramadan.

  • Alvin Rasmus
    Alvin Rasmus3 ditë më parë

    Why are youtube recommendations so great at 4 am!!! When I'm allowed to watch youtube they're all literal garbage

  • somebody
    somebody3 ditë më parë

    Just always have 10 missed calls fro mom. The cells will kick right in survival mode

  • quartytypo
    quartytypo3 ditë më parë

    Instead of looking for a job, I am staying home and watching Veritasium and other ALthe videos all day.

  • Daveraj singh gill
    Daveraj singh gill3 ditë më parë

    I think the question "Can we" is important, and should be explored, but more so, we should determine "Should we" I think the effects of Humans on the world in general is already horrible, and as time progresses, people seem to worsen as humans accordingly.

  • Brian Lam

    Brian Lam

    2 ditë më parë

    Well, the declining birth rates in japan and the US seem to show that eventually, human population will stagnate. Also, overpopulation due to indefinite lifespans is a myth. The 12th billionth human will never be born due decreasing child mortality rates, meaning more parents will have less children.

  • azim.syazwan
    azim.syazwan3 ditë më parë

    wolverine laugh hysterically*

  • xKeita
    xKeita3 ditë më parë

    if people can get the choice to extend their life then can the choice to end it be allowed pls

  • Tejas Patade
    Tejas Patade3 ditë më parë

    gimme that nmn mannnnnnn...

  • sotirios Chortogiannos
    sotirios Chortogiannos3 ditë më parë

    Why do people live different ages? Because everyone can control how long we live. The more we nurture ourselves. Take the time to discover our body needs. Recognize the power of cognitive thought and emotional effects. Adjust how we move and respect the physical aspects of our lives to reduce wear and tear. There is no limit to how long we can live once we learn how properly take care of ourselves. Why ware we living longer and longer as time goes on? Be positive, love and recognize how amazing you and every aspect of reality is. We all really live forever anyways.

  • Soft Maps

    Soft Maps

    3 ditë më parë

    The people in my life who ate very little turned out to live to 90 or 100.

  • phliip
    phliip3 ditë më parë

    awesome video. I could definitely see this Sinclair dude becoming a Marvel Super Hero/Villain in like 10/20 years... :-) looking foreword to it!

  • Gary Burgin Jr
    Gary Burgin Jr4 ditë më parë

    He repair, he protecc, but he mostly slows aging

    GREY ALIEN4 ditë më parë

    When humans say they are about to live forever thats when we are all about to die . you cant beat entropy

  • Tamar Lambert
    Tamar Lambert4 ditë më parë

    You know, the argument that "We shouldn't have life extension technology because only the wealthy would have access to it" is kinda non-applicable because there are already life-extending medical treatments that only the wealthy have (i.e. cancer treatments, organ-transplants, heart medication, etc). That's a lot like arguing "Cancer treatments cost $2500-$10,000 a month in the US, we shouldn't cure cancer because that cure would be so expensive only the rich would have access to it!"

  • lukisnootis
    lukisnootis4 ditë më parë

    this channel gives off the vibes vsauce used too. I feel like Michael is so robotic now and acts like a wizard of the internet.

  • Auckland 2020 New Zealand
    Auckland 2020 New Zealand4 ditë më parë

    where is the weed to feed all these people?

  • Autumn anne
    Autumn anne4 ditë më parë

    I would love to know the exact things he did to go from 60 to 31 !!

  • Tyrant Onion

    Tyrant Onion

    2 ditë më parë

    It has probably something to do with weight loss.

  • Djurdjix Radic
    Djurdjix Radic5 ditë më parë

    I just hope that in the future, people would be required to undergo long and rigorous tests in ethics, backround checks and other things if they wish to administer reverse aging onto themselves . Just imagine, a tyrannical sociopath living for like 150 yrs or more. And, imagine this thing tooo : not discriminating between the rich and the poor, nationalities and races, it should be available for everybody Oh man wouldn't that be a thing... I think we would drastically have to change the values of the system we live in order to give this amazing technology to the public

  • John Moseley
    John Moseley5 ditë më parë

    In addition to all those other things that one never does, what about restricting breathing?

  • Ken Hotte
    Ken Hotte5 ditë më parë

    so...we're ~ 20 years out from Wade Wilson.

  • The Gram
    The Gram5 ditë më parë

    Mice may have to eat less protein but we are carnivores

  • kapoios1453
    kapoios14535 ditë më parë

    So basically we need to live in survival conditions to live longer. CHALLENGE ACCEPTED

  • sacheera Edirisinghe
    sacheera Edirisinghe5 ditë më parë

    Buddhist monks dont eat at night, coincidence?

  • KPEC3arrival
    KPEC3arrival5 ditë më parë

    Dopamine is what shortens lives.

  • Vesna Sunrider
    Vesna Sunrider5 ditë më parë

    Can I be a human test subject for vertebrae de-aging? :D

  • Berbal
    Berbal5 ditë më parë

    I think we should just stop humanity to solve all earths problems.

  • Berbal


    5 ditë më parë

    With stop I mean: kill all of

  • 1stGuyGamez _
    1stGuyGamez _6 ditë më parë

    so as a teenager I must activate the “grow and reproduce” conditions till I stop growing, right

  • David Sypnicki

    David Sypnicki

    Ditë më parë

    Yah I was thinking the same thing save this stuff till we’re done growing. Don’t want to be stunted

  • 1stGuyGamez _
    1stGuyGamez _6 ditë më parë

    step 1: go to an aztec temple step 2: find a weird looking stone mask, put some of your blood on it and wear it step 3: ? step 4: profit

  • 1stGuyGamez _

    1stGuyGamez _

    2 ditë më parë

    @Blodify it’s a jojo reference

  • Blodify


    2 ditë më parë


  • Mrs. Marks
    Mrs. Marks6 ditë më parë

    That last bit about the mice and their eyes, is exciting and hopeful.

  • Ahmed Houri
    Ahmed Houri6 ditë më parë

    We need Derek from MPMD to rect to this

  • Gold Hunter
    Gold Hunter6 ditë më parë

    I think the powers that be want to milk us for all the taxes they can and then get rid of us. Like when yet again an inventor stumbles upon zero point energy.

  • joe mama
    joe mama6 ditë më parë

    18:28 if jelly fish hold the key longer life span and can regress to an earlier stage of their lifes then that explains why turtle can live hundreds of years, because they eat jelly fish. Im heading to my local fish market to buy jelly fish right now🤣😎

  • joe mama
    joe mama6 ditë më parë

    Those are the same things methheads do and the evidence show the exact opposite🤣

  • CrazyDragy
    CrazyDragy6 ditë më parë

    Quite brilliant, though I feel like a lot of people might be hoping to chase wrong things with this. But understanding more of human and general biology is always fascinating.

  • Rick Abrams
    Rick Abrams6 ditë më parë

    can we get an update to this video?

  • Quinn Smith

    Quinn Smith

    Ditë më parë

    There's always a lot of progress in geoscience (despite the field still being underfunded). I recommend reading Lifespan IO's Rejuvenation Roadmap which keeps track of close different lines of damage repair research are from entering into clinical trials.

  • ZaksWILL
    ZaksWILL6 ditë më parë


  • Create More Ash vs Evil Dead stuff NOW!
    Create More Ash vs Evil Dead stuff NOW!6 ditë më parë

    I think research would be better developed if we didn't have a monarchy monopoly economically give our poor Einsteins a chance and start spreading wealth around raise minimum wage etc.

  • Vynzography
    Vynzography6 ditë më parë

    14:19 Sunblock, eat less, eat less protein, HITT, be too cold or too hot.

  • Marlou Fat Jesus
    Marlou Fat Jesus6 ditë më parë

    When ancient people already knew this stuff but some assholes introduced the 3 times a day meal bs lol. Fasting is the key.

  • broskisephine
    broskisephine6 ditë më parë

    mousy's gonna be so sad when it's sibling dies because it aged faster :,(

  • Cold Sleep
    Cold Sleep6 ditë më parë

    Man you really need to buy a tripod lmao. The interviews with people where the shots jiggle and move around really detract from the interviews. Takes you out of focusing on the content.

  • juanio
    juanio6 ditë më parë

    Peoples bodies aren’t design to live forever messing with genes and playing God will not end good.

  • Adaptive Blur
    Adaptive Blur6 ditë më parë

    So...How can i change my biological age?

  • Myk Al
    Myk Al6 ditë më parë

    If Jurassic park has taught me anything. Can we and should we. Should be considered together. But ya. It's not hard to imagine rich people keeping it for themselves and basically creating sect of people who live substantially longer and have more control than the rest.. now that I say it outloud I wouldn't doubt it's already happening haha. Someone get me some foil.

  • Martin Odote
    Martin Odote7 ditë më parë

    Are our cells just playing a really long game of broken telephone?

  • Ten Deepfake
    Ten Deepfake7 ditë më parë

    Love science.

  • Rodro M
    Rodro M7 ditë më parë

    Be uncomfortably Hot or cold Someone living in the desert - are you challenging me?

  • Jukebox300
    Jukebox3007 ditë më parë

    The three blind mice should have just gotten gene therapy. Then they probably wouldn't have lost their tails.

  • Jukebox300
    Jukebox3007 ditë më parë

    7:17 Such a good question

  • Tamar Lambert
    Tamar Lambert7 ditë më parë

    Derek on how to reverse aging: "The mitochondria are the powerhouses of the cell"

  • B2 - Almario, Sean Anthony, Santos
    B2 - Almario, Sean Anthony, Santos7 ditë më parë

    Imagine if someone did say... "I'm 15 in Earth Years, but I'm 23 in Human Years."

  • Potiq
    Potiq7 ditë më parë

    Easy. If you want to become immortal in the future you have to agree to be sterilized. solid deal imo lol

  • Frank
    Frank7 ditë më parë

    eating is annoying anyway. I practice intermittent fasting often just because I'm too lazy to cook

  • james
    james7 ditë më parë

    Lemme guess Baby juice and vaccs?

  • Kelvin C
    Kelvin C7 ditë më parë

    So where can I buy NMN?

  • Mike Eisenburger
    Mike Eisenburger7 ditë më parë

    Look into HBOT (Hyperbaric Oxygen Therapy) being done now in Florida at The Villages.

  • mrawesomnable
    mrawesomnable7 ditë më parë

    Long term fasting has been shown to help clear out some of the damaged cells in your body!

  • Maxi Arleo
    Maxi Arleo7 ditë më parë

    @Dalasreview tenes que ver esto

  • elvin rosetes
    elvin rosetes8 ditë më parë

    Biological twin

  • Pola & Tiger
    Pola & Tiger8 ditë më parë

    We have good models of how memory works. Body body and mind are inseparable just now. And we do not have hardware for brains and body yet. Will take a long time.

  • Praecantetia
    Praecantetia8 ditë më parë

    Guess I was on the right track when it comes to being in the cold

  • Miubcdrb
    Miubcdrb8 ditë më parë

    If people were actually healthy the population wouldn’t really be that high. It’s the unhealthy morons who make babies cause they have nothing better to do other than have sex. They’re just not physically or mentally healthy enough to engage in anything else for pleasure.

  • Tomek S
    Tomek S8 ditë më parë

    Lastpass got less functional in free version and more expensive again.

  • Tis'ur"Master'"
    Tis'ur"Master'"8 ditë më parë

    Can scientists fix the MAGA and the Q?

  • Tis'ur"Master'"
    Tis'ur"Master'"8 ditë më parë

    I'm about 300 years old right now. Wished I looked like my 20's again. Now I look like my 30's...grrrr!!!

  • bamboleyo
    bamboleyo8 ditë më parë

    what currency would you accept to sell living forever? how scary would dying be after a billion years of living? would someone leave their bunker if they could naturally live forever but were prone to accidents???

  • DistinguishedColleague234
    DistinguishedColleague2348 ditë më parë

    This guy looks like a 1940’s German scientist who’s prolonged his life

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